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KMID : 1038620160340030177
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Radiation Oncology Journal
2016 Volume.34 No. 3 p.177 ~ p.185
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Preoperative chemoradiotherapy followed by local excision in clinical T2N0 rectal cancer
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Shin Seob-Young
Yoon Yong-Sik
Lim Seok-Byung
Yu Chang-Sik
Kim Tae-Won
Chang Heung-Moon
Park Jin-hong
Ahn Seung-Do
Lee Sang-Wook
Choi Eun-Kyung
Kim Jin-Cheon
Kim Jong-Hoon
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Abstract
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Purpose: To investigate whether preoperative chemoradiotherapy (PCRT) followed by local excision (LE) is feasible approach in clinical T2N0 rectal cancer patients.
Materials and Methods: Patients who received PCRT and LE because of clinical T2 rectal cancer within 7 cm from anal verge between January 2006 and June 2014 were retrospectively analyzed. LE was performed in case of a good clinical response after PCRT. Patients’ characteristics, treatment record, tumor recurrence, and treatment-related complications were reviewed at a median follow-up of 49 months.
Results: All patients received transanal excision or transanal minimally invasive surgery. Of 34 patients, 19 patients (55.9%) presented pathologic complete response (pCR). The 3-year local recurrence-free survival and disease free-survival were 100.0% and 97.1%, respectively. There was no recurrence among the patients with pCR. Except for 1 case of grade 4 enterovesical fistula, all other late complications were mild and self-limiting.
Conclusion: PCRT followed by an LE might be feasible as an alternative to total mesorectal excision in good responders with clinical T2N0 distal rectal cancer.
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KEYWORD
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Radiotherapy, Rectal neoplasms, Neoadjuvant therapy, Transanal endoscopic microsugery
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